The Biological Role of the Signal Transducer and Activator of Transcription 1 (STAT1)-miR-221/222-3p-p21 Activated Kinase 1 (PAK1) Axis in Experimental Periodontitis.

ABSTRACT: Periodontitis is a chronic inflammatory disease characterized by the progressive destruction of tooth-supporting tissues. Despite extensive research, the molecular mechanisms underlying its pathogenesis remain incompletely understood. This study aimed to investigate the role and regulatory mechanisms of miR-221/222-3p in experimental periodontitis. The expression of miR-221/222-3p in lipopolysaccharide (LPS)-stimulated periodontal ligament cells (PDLCs) and ligation-induced rat periodontitis were detected by RT-qPCR. miR-221/222-3p agomir were administrated topically in ligation-induced rat periodontitis. The therapeutic function of both miRNAs were assessed by micro-CT, TRAP staining, and immunohistochemistry. The mechanisms of miR-221/222-3p function in periodontitis were determined by c

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12722484 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature