Waning in influenza vaccine effectiveness against influenza A(H1N1)pdm09-associated hospitalization in children in 2012/2013.

ABSTRACT: Measuring waning in vaccine effectiveness (VE) is challenging due to potential depletion-of-susceptibles bias. Some SARS-CoV-2 studies excluded individuals with prior infection and adjusted for the probability of remaining uninfected. We applied this approach to assess waning influenza VE in Hong Kong during the 2012/2013 season. First, we estimated the infection risk for unvaccinated children using published serological and surveillance data. Next, we derived infection risk for vaccinated children, assuming VE against infection of 57%. Uncorrected VE from 14 to 270 days post-vaccination was estimated from hospitalized children. We calculated the rate of depletion of susceptibles given infection risk and VE corrected for depletion-of-susceptibles bias. Waning rates for uncorrected and bias

SUBMITTER: Chua HY 

PROVIDER: S-EPMC12722548 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature