Uncovering pathology, subjective cognitive complaints, and sex in early Alzheimer's disease.

ABSTRACT: BackgroundSubjective cognitive complaints may correlate with cerebral amyloid-β (Aβ) levels in the early phases of Alzheimer's disease (AD). The relationship between sex, AD pathology, and complaints remains unclear.ObjectiveOur study aims to (1) explore the relationship between Aβ pathology, assessed with two complementary measures, and subjective cognitive complaints across multiple domains in cognitively unimpaired (CU) individuals and those with mild cognitive impairment (MCI); (2) assess which subjective cognitive complaints can differentiate Aβ-positive from Aβ-negative individuals, CU from MCI, and progressors from non-progressors; and (3) evaluate sex differences in these relationships.MethodsIn 418 CU older adults and 408 with MCI from the ADNI cohort, we examined associations bet

SUBMITTER: Boutin S 

PROVIDER: S-EPMC12722564 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature