Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression.

ABSTRACT: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, underscoring the need for deeper insights into its molecular mechanisms. The SRY-box transcription factor 9 (SOX9) is a well-characterized oncoprotein critical for the pathogenesis and progression of multiple cancers, including NSCLC. However, the post-translational mechanisms governing SOX9 stability, particularly those mediated by arginine methyltransferases, are poorly defined. In this study, we identify protein arginine methyltransferase 7 (PRMT7) as a novel regulator of SOX9. We demonstrate that PRMT7 directly interacts with SOX9 and enhances its stability in a methyltransferase-dependent manner. Mechanistic investigations reveal that PRMT7 catalyzes mono-methylation of SOX9 at the argini

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12722591 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature