Brahmi (Bacopa monnieri) plant preparation facilitates to enhance the activities of dendritic cells to control non-small cell lung cancer (NSCLC).

ABSTRACT:

Background

Brahmi (Bacopa monnieri) plant preparation (BPP) has been recognizedfor its immunomodulatory capabilities, but its molecular and epigenetic effects onimmune cells in non-small cell lung cancer (NSCLC) remain unknown.

Objective

Thisstudy investigated the way BPP influenced the molecular phenotype and functionalprofile of monocyte-derived dendritic cells (DCs) derived from an NSCLC patient anda healthy donor.

Result

BPP treatment enhanced DC maturation, as demonstrated byelevated levels of CD1d and co-stimulatory molecules (CD80/CD86), and conditionedsupernatants that efficiently activated autologous T cells. BPP increased proinflammatorysignaling molecules STAT1, STAT2, STAT4, and total NF-κB, whiledecreasing STAT3, STAT5, STAT6, and the DNA-repair protein D

SUBMITTER: Kumar RI 

PROVIDER: S-EPMC12722597 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature