Implementing robust amyloid PET quantification in multi-center studies: AMYPAD approach to address data acquisition, processing, interpretation and data sharing challenges.

ABSTRACT:

Introduction

Amyloid-positron emission tomography (PET) is pivotal to Alzheimer's management, with the Centiloid standardizing measurements across tracers. AMYPAD trials (Diagnostic and Patient Management Study [DPMS] and Prognostic and Natural History Study [PNHS]) aimed to validate robust quantification in clinical settings. We report our comprehensive approach to amyloid-PET implementation, comprising scan acquisition, harmonization, data storing, and data sharing strategies.

Methods

Data from 28 scanners were harmonized using Hoffman phantoms. Three quantification workflows were compared: AmyPype (PET-only), IXICO-LEAP, and the standard Centiloid pipeline (magnetic resonance imaging [MRI]-based). Distributions of Centiloids were assessed using Gaussian Mixture Modeling.<

SUBMITTER: Bollack A 

PROVIDER: S-EPMC12722600 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature