Multiparameter MRI assessment of metformin and exercise effects on skeletal muscle in prediabetes: a randomized controlled trial.

ABSTRACT:

Background

The metabolic effects of combined metformin and aerobic exercise on skeletal muscle in prediabetes remain unclear. We evaluated individual and combined effects on skeletal muscle metabolism using multiparameter magnetic resonance imaging (MRI) and assessed prediabetes remission.

Materials and methods

In this 12-week randomized controlled trial, forty-two prediabetic adults aged 48.4 ± 13.1 years mean ± standard deviation) were randomized into control (n = 10), metformin (n = 10), exercise (n = 11), and combined therapy (n = 11) groups. Multiparameter MRI measured T2, apparent diffusion coefficient (ADC), fractional anisotropy (FA), intermuscular adipose tissue (IMAT), intramyocellular lipids, visceral adipose tissue (VAT), and muscle cross-sectional areas (MSCAs).

SUBMITTER: Yu F 

PROVIDER: S-EPMC12722603 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature