Novel common target genes for breast cancer and colorectal cancer: a Mendelian randomization and spatial transcriptomics study.

ABSTRACT:

Introduction

Breast and colorectal cancer are a major global public health problem. Breast cancer is one of the most common cancers worldwide. Colorectal cancer is the third most common cancer and the second most common cause of tumor death worldwide. Central memory T (TCM) cells are closely related to the development of tumors and important targets for immunotherapy. Therefore, identifying the common signaling molecules of these two diseases in TCM cells can improve our understanding of these diseases and lead to the development of therapies that can be effective for treating both.

Methods

Single-cell RNA (scRNA) data of breast cancer (GSE161529) and colorectal cancer (GSE222300) patients was downloaded from the GEO database. The data were normalized and dimension reduced,

SUBMITTER: Miao P 

PROVIDER: S-EPMC12722630 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature