Reduced-Dose Versus Full-Dose Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism.

ABSTRACT: BackgroundVenous thromboembolism (VTE) often necessitates extended anticoagulation to reduce the risk of recurrence. While direct oral anticoagulants (DOACs) have largely replaced vitamin K antagonists due to their improved safety and convenience, the optimal long-term dosing strategy (reduced vs full dose) remains uncertain. This systematic review assesses the efficacy and safety outcomes of reduced-dose DOACs compared with full-dose therapy for extended VTE treatment.MethodsWe conducted a systematic review of randomized controlled trials (RCTs) comparing reduced-dose and full-dose DOACs in patients with VTE. Due to heterogeneity in study designs and outcomes, a narrative synthesis was performed.ResultsThree RCTs were included. In AMPLIFY-EXT, recurrent VTE or death occurred in 1.7% of pa

SUBMITTER: Deng D 

PROVIDER: S-EPMC12722643 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature