Multiple sclerosis relapse risk factors across treatment eras.

ABSTRACT:

Background

Age and sex were shown to influence multiple sclerosis (MS) relapse activity in the 1990s. Whether relapse risk factors are the same with new treatment paradigms is unclear. We evaluate predictors of clinical relapse following the first clinic visit (FV) across different treatment eras in a large, retrospective cohort.

Methods

Adults with clinically isolated syndrome or relapsing-onset MS were divided into cohorts with FV at the Brigham Multiple Sclerosis Center (Boston, MA) from 1997 to 2010 ("early") and 2010 to 2020 ("recent"). Risk factors for relapse in 3 years after the FV were assessed for each cohort using multivariable logistic regression, and interaction terms were evaluated.

Results

2192 patients were included (early: 1536; recent: 656). Younger

SUBMITTER: Madill E 

PROVIDER: S-EPMC12722674 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature