Antibiotic use and survival from breast cancer: A population-based cohort study in England and Wales.

ABSTRACT: The role of the gut microbiota in carcinogenesis is increasingly being acknowledged. Recent studies in multiple breast cancer mouse models have found that antibiotics, by altering the gut microbiota, can accelerate tumour growth. In humans, a recent cohort study restricted to triple negative breast cancer showed that breast cancer patients using a greater number of antibiotics had markedly worse survival. These studies have raised concerns about repeated antibiotic use in breast cancer patients. In this Registered Report, we investigated whether breast cancer patients using oral antibiotics had increased breast cancer-specific mortality. In population-based cohorts (n = 44,452), we did not observe a statistically significant association between antibiotic prescriptions after diagnosis and

SUBMITTER: Cardwell CR 

PROVIDER: S-EPMC12722697 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature