Multi-pathway regulatory role of miR-4693-5p in the modulation of rheumatoid arthritis.

ABSTRACT: Rheumatoid arthritis (RA) is a chronic autoimmune condition that typically causes inflammation in joints symmetrically. Dysregulated microRNAs are implicated in RA development. Our earlier findings showed that miR-4693-5p levels were decreased in PBMCs isolated from RA patients, impacting apoptosis, inflammatory cytokines production, and reactive oxygen species (ROS) response. This study investigated the regulatory influence of TNF-α on the expression of miR-4693-5p and examined the downstream effects of miR-4693-5p on key proteins and pathways associated with RA. The objective is to elucidate the therapeutic potential of miR-4693-5p in disease. The impact of TNF-α on miR-4693-5p expression in SW982 cells was assessed using qRT-PCR. Differential protein analysis was performed using SWATH-M

SUBMITTER: Saquib M 

PROVIDER: S-EPMC12722704 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature