Is tranexamic acid effective for all traumatic brain injury patients? a severity based systematic review and meta-analysis.

ABSTRACT:

Background

The effectiveness of tranexamic acid (TXA) in patients with traumatic brain injury (TBI) remains controversial and appears to vary with the severity of the injury. This systematic review and meta-analysis aimed to assess the impact of TXA on mortality in patients with mild to moderate TBI and severe TBI.

Methods

A systematic search was conducted across PubMed, Embase, Web of Science, Cochrane Library database, Chinese CNKI database, and clinical trial repositories was conducted up to 1 May 2024. Studies comparing TXA with placebo were performed for relevant studies comparing TXA for mild to moderate and severe TBI were included. After literature screening, data were independently extracted and pooled using random-effects or fixed-effects models according to the ma

SUBMITTER: Bian W 

PROVIDER: S-EPMC12722793 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature