How do psychedelics impact people with a history of non-affective psychosis? A qualitative study.

ABSTRACT:

Background

People with a history of psychotic disorders are excluded from contemporary trials of psychedelic-assisted therapy. Although survey studies have explored the impact of naturalistic psychedelic use on people with a history of psychotic disorders, a qualitative study has yet to examine the subjective effects of psychedelic use in this population during both the acute effects and perceived long-term impacts.

Method

Two semi-structured in-depth interviews were conducted with participants (n = 19) who had used psychedelics after the diagnosis of non-affective psychotic disorders (NAPD). Interviews probed the perceived positive and negative effects of psychedelic use. Data were analyzed using reflexive thematic analysis.

Results

We constructed three major themes:

SUBMITTER: Dourron HM 

PROVIDER: S-EPMC12722819 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature