Serum luteinizing hormone trajectories during ovarian stimulation and their outcomes of IVF/ICSI: a retrospective cohort study.

ABSTRACT:

Background

An appropriate luteinizing hormone (LH) level during ovulation stimulation (OS) is important for positive in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes. Although the gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol can inhibit a premature rise of LH, it remains ineffective in some patients. This study aimed to identify the characteristics of patients who shared similar underlying LH trajectories and to determine how different serum LH trajectories influence IVF/ICSI outcomes.

Methods

This study was a retrospective cohort study that included 2,716 patients who underwent GnRH-ant protocol for OS from 1 January 2017 to 31 June 2024. Multiple serum LH measurements during OS were collected. Group-based trajectory model

SUBMITTER: Liu C 

PROVIDER: S-EPMC12722849 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature