Organ-specific role of neutrophil extracellular traps in shaping the postoperative thrombo-inflammatory niche in pancreatic ductal adenocarcinoma: a multi-model machine learning and mechanistic study.

ABSTRACT:

Background

Neutrophil extracellular traps (NETs) play a crucial role in thrombosis formation and tumor progression. However, the association between NETs and portal vein thrombosis (PVT) is not well understood.

Methods

We retrospectively and prospectively developed and validated a predictive model for postoperative PVT following radical surgery for pancreatic ductal adenocarcinoma (PDAC) from Jan. 2011 to Dec. 2022 and Jan. 2023 to Dec. 2023. 30 clinicopathological variables, including the novel biomarker NETs, were evaluated. 11 ML algorithms were compared based on several evaluation indexes including AUC. SHapley Additive exPlanations (SHAP) analysis was utilized for feature ranking and interpretability.

Results

In the retrospective study, a total of 306 patients we

SUBMITTER: Cui S 

PROVIDER: S-EPMC12722873 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature