A self-reinforcing nanoplatform for triple-synergistic therapy: NIR-triggered photothermal/gas/chemodynamic therapy of tumors.

ABSTRACT:

Introduction

A major challenge in nanomedicine is developing multifunctional nanoplatforms capable of achieving synergistic cancer therapy.

Methods

In the present study, we developed a CD44-targeted nanocomposite, named UiO-SNO@CuS/HA, for efficacy evaluation in combination therapy including photothermal therapy (PTT), nitric oxide (NO) gas therapy and chemodynamic therapy (CDT) The nanoplatform was produced through the preparation of UiO-66-SH metal-organic framework (MOF) followed by the post-synthetic nitrosation of S-thiols to give S-nitrosothiols (SNO) as the NO donor. Afterward, in situ growth of ultrasmall CuS nanoparticles on the MOF surface led to the eventual coating of the hybrids with hyaluronic acid (HA) for active tumor targeting.

Results

Under 1064 nm l

SUBMITTER: Xue Y 

PROVIDER: S-EPMC12722887 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature