Citywide community-based colorectal cancer screening in urban Shanghai: age and sex variations in risk mitigation from 1973 to 2020.

ABSTRACT:

Aims

To evaluate the impact of Shanghai's community colorectal cancer (CRC) screening program on CRC epidemiology and risk reduction.

Materials and methods

Data from the Shanghai Cancer Registry (1973-2020) were analyzed. Launched in 2013, the program targets residents aged 50-74, offering free risk assessment (questionnaire and fecal tests). High-risk individuals are advised for colonoscopy (non-mandatory). Interrupted time-series analysis assessed age-standardized incidence and mortality trends.

Results

Over 3 million individuals were screened, with 18.7% high-risk and 27-32% undergoing colonoscopy. Screening did not significantly reduce CRC incidence but led to a mortality decline (annual percent change [APC]: 1.07% to -3.16%, P < 0.001). Females showed grea

SUBMITTER: Wu M 

PROVIDER: S-EPMC12722893 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature