Sialylation-related gene signature predict prognosis and immunotherapy efficacy in low- and high-grade glioma: a PCA-based stratification study.

ABSTRACT:

Background

Sialylation is a crucial glycosylation modification of eukaryotic cell surface proteins. Tumor cell growth, immune evasion, and drug resistance are driven by excessive sialylation. However, the expression levels of genes associated with sialylation, prognostic value, and impact on the response to immunotherapy in brain tumors remain unclear. This study hypothesized that sialylation-related genes could serve as grouping genes to identify 20 significant genes for predicting the survival outcomes of patients with brain tumors and their responsiveness to immune checkpoint inhibitors.

Methods

Using 83 genes related to sialylation, we classified the cohort into two distinct groups with marked differences in survival outcomes and immune cell infiltration. After identifyi

SUBMITTER: Zhu G 

PROVIDER: S-EPMC12722909 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature