Limitations of PICADAR as a diagnostic predictive tool for primary ciliary dyskinesia.

ABSTRACT:

Background

The Primary Ciliary Dyskinesia Rule (PICADAR) is a diagnostic predictive tool currently recommended by the European Respiratory Society (ERS) to assess the likelihood of a primary ciliary dyskinesia (PCD) diagnosis. Despite its recommendation according to the current ERS PCD diagnostic guideline, the performance of the PICADAR remains insufficiently studied.

Methods

We evaluated the sensitivity of PICADAR in 269 individuals with genetically confirmed PCD. Using an initial question, PICADAR rates all individuals without daily wet cough negative for PCD. PICADAR evaluates seven questions in the daily wet cough group. We here calculated test sensitivity based on the proportion of individuals scoring ≥5 points as recommended. Subgroup analyses examined the impact of l

SUBMITTER: Schramm A 

PROVIDER: S-EPMC12722925 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature