Maternal hypertensive disorders during pregnancy and their link to childhood asthma: a systematic review and meta-analysis.

ABSTRACT:

Objective

The association between Hypertensive Disorders of Pregnancy (HDP) and childhood asthma remains controversial, with limited systematic synthesis. This study aimed to integrate global observational evidence to evaluate the relationship between HDP [and its subtypes, pre-eclampsia (PE) and gestational hypertension (GH)] and offspring asthma risk, while exploring sources of heterogeneity.

Methods

Following PRISMA 2020 and MOOSE guidelines, 20 observational studies (n = 9,447,593) were identified via systematic searches in Cochrane Library, PubMed, Web of Science, and ScienceDirect (up to January 2025). Random-effects meta-analysis pooled odds ratios (ORs), with subgroup analyses for HDP subtypes, geographic regions, and offspring age. Quality was assessed using

SUBMITTER: Jia Y 

PROVIDER: S-EPMC12722935 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature