Effects of methylphenidate on children with attention deficit hyperactivity disorder: a study using clinical and multimodal approaches including go/no-go task and functional near-infrared spectroscopy.

ABSTRACT:

Objective

This study aims to provide an objective evaluation of the therapeutic effects of methylphenidate (MPH) in children with attention deficit hyperactivity disorder (ADHD) by integrating clinical assessments, the go/no-go task, and functional near-infrared spectroscopy (fNIRS).

Methods

This study employed a two-part design. First, a cross-sectional comparison was conducted between 36 children with ADHD and 12 typically developing controls (TDC) to establish baseline neurocognitive and functional differences. Second, a pre-post intervention design was used to evaluate the effects of a 6-month MPH treatment on the 36 children with ADHD. All participants underwent clinical assessments, including the Swanson, Nolan, and Pelham IV Rating Scale (SNAP-IV) and the Weiss Functi

SUBMITTER: Shen F 

PROVIDER: S-EPMC12723010 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature