A lactobacilli-based probiotic but not its postbiotic reduces intestinal inflammatory pathways expression in broilers fed a non-starch polysaccharide rich challenge diet.

ABSTRACT: Diets rich in non-starch polysaccharides (NSP) are known to challenge broiler growth and induce gut inflammation. Here, a lactobacilli-based probiotic (Pro) and its derived postbiotic (Post) were investigated when supplemented to an NSP-rich challenge diet (Ctrl) fed to broilers reared under commercial conditions. Treatments had 8 pen replicates with 40 broilers each. On day 35, for 3 broilers/pen, the microbiota, volatile fatty acids and semi-polar metabolome composition were determined in ileal and caecal digesta. In addition, changes in the transcriptome of jejunal, ileal and caecal tonsil tissues as well as in the blood were investigated by RNA-seq. Apparent ileal nutrient digestibility and tibia health were also assessed. The Pro affected the relative abundance of four operational tax

SUBMITTER: Jansseune SCG 

PROVIDER: S-EPMC12723048 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature