Temporal changes in native and late gadolinium enhanced ultrashort echo time magnetic resonance imaging during gynecologic cancer radiation therapy.

ABSTRACT:

Background and purpose

Radiotherapy (RT) response in gynecologic cancers varies widely and is influenced by several factors. We evaluated whether fibrosis detected with inversion-recovery ultrashort-echo-time (IR-UTE) MRI (magnetic-resonance-imaging) signal-intensity (SI) could serve as noninvasive biomarkers of treatment response in patients imaged serially during external-beam RT (EBRT) and brachytherapy (BT).

Materials and methods

Patients: Fifteen patients with gynecologic cancer were included. Five participants underwent seven MRIs: pre-RT, weeks 1 (RT_wk1), 2 (RT_wk2), and 3 (RT_wk3) of EBRT, post-EBRT, 1-week post-BT, and 12 weeks post-BT. Ten participants did not receive MRI in RT_wk1, RT_wk2, or 1-week post-BT

SUBMITTER: Sheikh K 

PROVIDER: S-EPMC12723059 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature