The impact of <i>APOE</i> ε4 on cognition in Brazilians with type 2 diabetes: exploring ethnicity effects.

ABSTRACT:

Introduction

Type 2 diabetes (T2D) is associated with cognitive decline, but the role of APOE ε4 - a known Alzheimer's risk allele - in cognition among admixed populations with T2D remains unclear.

Methods

We analyzed 883 Brazilian adults with T2D (median age 68 years) from primary care, excluding those with dementia. Cognitive function was assessed using Mini-Mental State Examination (MMSE), and APOE genotypes were determined. MMSE errors were modeled using negative binomial regression.

Results

APOE alleles showed no association with MMSE errors overall. Older age and self-reported Black/Brown race predicted more errors, whereas higher education and physical activity predicted fewer. Sensitivity analyses indicated a possible inverse association b

SUBMITTER: Nohmi RL 

PROVIDER: S-EPMC12723071 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature