Selection of Common Genes Associated with Rheumatoid Arthritis and Cardiovascular Disease via a Network- and Pathway-Based Approach.

ABSTRACT:

Background

Patients with rheumatoid arthritis (RA) have an increased risk of developing cardiovascular disease (CVD). However, the mechanisms underlying the comorbidity between RA and CVD remain poorly understood. This study aimed to identify the shared genes between RA and CVD and to explore their functional relationships.

Methods

Rheumatoid arthritis- and CVD-associated genes were obtained from the DisGeNET and Malacards databases, respectively. Shared genes between the 2 diseases were identified, and gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using WebGestalt and Cytoscape (v3.9.0). To further investigate potential molecular interactions, protein-protein interaction networks were constructed based on data from the

SUBMITTER: Bai Y 

PROVIDER: S-EPMC12723107 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature