The cumulative impact of fine particulate matter exposure on hippocampal volume and working memory: Insights from prenatal and adolescent exposures from the ABCD study.

ABSTRACT:

Background

Global warming, urbanization, coal-burning pollution, and global wildfires draw attention to the necessity of bridging gaps in our current understanding of the effects of fine particulate matter (PM_2.5) on neurodevelopment. Despite evidence of environmental contaminants having deleterious effects on cognition and neurodevelopment in particularly sensitive areas like the hippocampus that have prolonged plasticity, much of this work examines a single time point (e.g., prenatal exposure) in single site studies. As a result, it is unclear whether deleterious effects accumulate over development.

Methods

The Adolescent Brain Cognitive Development study (aged 8.9-11.1 years; 47.1 % female) provides a geographically broad and racially diverse sample (66.1 % Whi

SUBMITTER: Damme KSF 

PROVIDER: S-EPMC12723120 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature