Insulin Resistance and Cognitive Function in Nondiabetic Patients With Cerebral Small Vessel Disease: Role of Brain Glymphatic Function.

ABSTRACT:

Objective

Both insulin sensitivity and brain glymphatic function were linked to cognitive function in nondiabetic patients with cerebral small vessel disease (CSVD). This study aims to elucidate these complex associations through mediation analysis.

Methods

Patients who underwent multimodal magnetic resonance imaging (MRI) scans were recruited. Global cognitive assessment was performed by Mini-Mental State Examination (MMSE), four isolated cognitive domains were assessed simultaneously. Glymphatic function was assessed using the diffusion tensor imaging along the perivascular space (DTI-ALPS) index, insulin sensitivity was assessed by the homeostasis model assessment-estimated insulin resistance index (HOMA-IR), and HOMA-IR≥2.80 was defined as insulin resistance (IR). Mediat

SUBMITTER: Yang XL 

PROVIDER: S-EPMC12723189 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature