Mitochondrial Dysfunction Induced by a Novel Salicylate-Based 1,2,3-Triazole Salt With Potent Antileishmanial Activity.

ABSTRACT: Leishmaniasis is a neglected disease caused by Leishmania spp., with limited treatment options and no available vaccine. In this study, novel 1,2,3-triazole derivatives 4-substituted with salicylic esters and their salts were synthesized and evaluated against L. amazonensis. While neutral compounds were inactive, their salts effectively inhibited both promastigote and intracellular amastigote growth. Compound 7 exhibited the highest antileishmanial activity and selectivity (IC₅₀ against amastigotes of 6.23 ± 0.35 μM; SI of 17.81), surpassing miltefosine, the positive control. Additionally, this compound exhibited no hemolytic effect. Studies further demonstrated that at early time points (6 h), treatment with compound 7 led to a marked increase in total ROS and mitochondrial sup

SUBMITTER: De Oliveira BA 

PROVIDER: S-EPMC12723204 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature