Expanding the actinomycetes landscape for phosphonate natural products through genome mining.

ABSTRACT: Phosphonate natural products (P-NPs) represent a unique and underexplored class of bioactive compounds with significant pharmaceutical and biotechnological potential. Many novel P-NPs with promising bioactivities were identified in recent years by genome mining of actinomycetes. The DSMZ strain collection harbors more than 6000 actinobacterial strains including an increasing number of genome sequenced strains. In this study, 940 genome-sequenced actinomycetes from the DSMZ and University of Tübingen strain collections were screened for the presence of phosphonate biosynthetic gene clusters (P-BGCs) by searching for the conserved pepM gene. This effort led to the identification of 54 potential phosphonate producer strains. Subsequent bioassays with a phosphonate-sensitive E. coli<

SUBMITTER: Zimmermann A 

PROVIDER: S-EPMC12723261 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature