Light-Mediated Supramolecular Functionalization of Polymerization-Induced Self-Assembled Micelles.

ABSTRACT: Precise, remote control of polymeric nanoparticles via external stimuli is a key aim for the next-generation drug delivery. As a versatile, one-pot method, polymerization-induced self-assembly (PISA) produces dispersions of block-copolymer micelles at high solids content with tunable core-corona architectures. Light is an ideal trigger to control the uptake and delivery of specific molecules inside such micelles since it can be localized, and easily tuned in intensity and wavelength. In this study, PISA is employed in water to obtain micelles containing diacylaminopyridine units functionalizable thanks to supramolecular interaction by a light-mediated process. Indeed, only if UV irradiation is used to convert thymine-based azo photoswitches into the cis form, these molecules permeate the h

SUBMITTER: Rossi R 

PROVIDER: S-EPMC12723323 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature