Design of a Trigger-Responsive Photothermal Vesicle-Based Cargo Delivery Platform.

ABSTRACT: Cargo delivery systems enable the targeted transport of therapeutic agents to specific sites, enhancing treatment efficacy while minimizing systemic side effects. However, many existing systems struggle with achieving precise control over the release timing. Here, a photothermal trigger-responsive delivery platform based on Giant Unilamellar Vesicles (GUVs) functionalized with gold nanorods (GNRs) is described to overcome these challenges. Toward this end, cargo-loaded GUVs are produced using the emulsion transfer method and effective GNR attachment to the vesicle membrane is achieved by functionalizing the GNRs with cholesterol. The near-infrared light (NIR)-mediated cargo release mechanism is described. Importantly, high release efficiency is achieved by optimizing the cholesterol concen

SUBMITTER: Schramm A 

PROVIDER: S-EPMC12723353 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature