Alterations in gut microbiota composition in neurodevelopmental disorders: a systematic review and meta-analysis.

ABSTRACT:

Background

Neurodevelopmental disorders (NDDs) have been linked to changes in the gut microbiome, but the exact nature of these alterations is not fully understood. This research seeks to explore the variations in both the diversity and composition of the gut microbiota in individuals diagnosed with NDDs.

Methods

We conducted a systematic literature search up to April 2025. Meta-analyses using STATA 16.0 evaluated alpha diversity, beta diversity, and relative abundance between individuals with NDDs and healthy controls.

Results

No significant alpha diversity differences were found between NDD and control groups. Beta diversity analysis revealed distinct microbial communities across autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and ti

SUBMITTER: Yang H 

PROVIDER: S-EPMC12723412 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature