The role of sestrin2 in skeletal muscle regeneration after injury.

ABSTRACT: Despite advances in the understanding of muscle degeneration, the mechanisms governing muscle regeneration under stress conditions remain poorly defined. Sestrin2 (Sesn2) is a stress-inducible gene that plays a crucial role in metabolic balance, nutrient sensing, and redox homeostasis, while protecting against muscle atrophy through multiple pathways. However, its precise role in skeletal muscle differentiation and regeneration, particularly under injury conditions, remains incompletely understood. In this study, we investigated the role of Sesn2 in skeletal muscle homeostasis and regeneration using in vitro and in vivo models, complemented by transcriptome analyses. Sesn2 knockdown in C2C12 myoblasts induced senescence-like morphological changes, accompanied by upregulation

SUBMITTER: Hwang CY 

PROVIDER: S-EPMC12723418 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature