Fluorescence Visualization of Helix Inversion in Biomimic Polymeric Foldamer.

ABSTRACT: Biomacromolecules such as DNA, proteins, and polysaccharides possess unique helical structures that are closely related to their biological functions involving recognition, catalysis, replication, and genetic information storage. From a biomimetic perspective, artificial foldamers are the ideal systems to model and study the structure-property relationship of biomacromolecules. Herein, we report a facile, rapid, and cost-effective method to directly visualize and monitor the solvent-driven helix inversion in a water-soluble poly(m-phenylene ethynylene)-based foldamer with the aid of a tetraphenylethene-functionalized hemicyanine dye. By adjusting the solvent environment, the foldamer transitions from an M-helix to a P-helix, accompanied by a change in the dye's binding mode from groove to

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC12723458 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature