Synthesis, antibacterial activity, and mechanistic characterization of novel 9-substituted berberine derivatives.

ABSTRACT: Natural products serve as valuable sources for developing antibacterial agents. In this study, 35 berberine derivatives were synthesized, and preliminary screening revealed that most compounds effectively inhibited the growth of Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Notably, B12-loaded HAMA/PEGDA hydrogels exhibited a sustained-release profile that ensured prolonged local exposure and produced significant antibacterial effects in an MRSA-infected wound mouse model. Furthermore, B12 showed potent antibacterial and therapeutic effects in a P. aeruginosa-induced bacterial pneumonia-associated acute lung injury model. Mechanistically, B12 reduced bacterial loads in skin and lung tissues, suppressed pro-inflammatory cytokine expressi

SUBMITTER: Tong J 

PROVIDER: S-EPMC12723511 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature