Injectable Nanocomposite Biomaterial for 3D Printing of Personalized Matrices and Their Use in Bioreactors for Bioengineering Advanced Cell Culture Models.

ABSTRACT: Printing technology is a leading strategy for creating customized 3D matrices for tissue engineering. Our study developed an injectable nanocomposite hydrogel (bHAGel) for high-fidelity 3D extrusion printing composed of gelatin (Gel) and magnesium-doped biomimetic hydroxyapatite (bHA) particles that mimics a bone extracellular matrix. bHA particles, synthesized through a bioinspired mineralization process, acted as multifunctional additives, modulating rheology for printability, ensuring homogeneous phase distribution, enabling excellent model fidelity, and providing osteoinductive cues. The optimized hydrogel formulation enables the fabrication of porous scaffolds with interconnected macro- and microporosity via extrusion-based printing and freeze-drying. This key feature promoted cell in

SUBMITTER: Campodoni E 

PROVIDER: S-EPMC12723638 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature