Reviving the Fight against Opioid Overdoses: Unleashing the Power of Metal-Organic Frameworks for Morphine Removal.

ABSTRACT: The lack of suitable medical adsorbents that exhibit a quick response at the time of an overdose is challenging. In this work, we focused on morphine (MORPH) adsorbents that efficiently abate MORPH during the acute overdose and provide, in a controlled, gradual manner, MORPH antagonist─naloxone (NAL) to effectively and safely reverse overdose and its side effects by using, as sorbent, zirconium metal-organic frameworks (MOFs). Three model MOFs, including UiO-66, UiO-67, and NU-1000, were characterized in terms of their ability to adsorb MORPH as well as NAL release in water and a simulated body fluid (SBF). Single MORPH adsorption on NU-1000 was 100% in water and 90 wt % in SBF solution. At the same time, in a single NAL release in SBF from the prepared NAL@UiO-67 composite was equal to 76

SUBMITTER: Hyjek K 

PROVIDER: S-EPMC12723641 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature