Luminescent Cyclometalated Iridium(III) Polypyridine Complexes Modified with a Dendritic Guanidinium Moiety as Molecular Glues for Combined Chemo-Photodynamic Therapy.

ABSTRACT: We report herein three cyclometalated iridium(III) polypyridine complexes appended with a dendritic guanidinium unit [Ir(N^C)₂(bpy-Gu₉)](Cl)₁₀ (bpy-Gu₉ = 4-(N-(3,4,5-tris(2-(2-(2-(4-((3,4,5-tris(2-(2-(2-guanidinoethoxy)ethoxy)ethoxy)benz-amido)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)phenylcarbonyl)aminomethyl)-4'-methyl-2,2'-bipyridine; HN^C = 2-phenylpyridine (Hppy) (1a), 2-phenylquinoline (Hpq) (2a), and 2-(1-naphthyl)benzothiazole (Hbsn) (3a)) as molecular glues. Their guanidinium-free counterparts [Ir(N^C)₂(bpy-C4)](Cl) (bpy-C4 = 4-(N-(n-propylcarbonyl)aminomethyl)-4'-methyl-2,2'-bipyridine; HN^C = Hppy (1b), Hpq (2b), and Hbsn (3b)) were also isolated

SUBMITTER: Wang JH 

PROVIDER: S-EPMC12723684 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature