Tirzepatide for sleep-disordered breathing in SURMOUNT-OSA: Time course and association with body weight.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) is a common disorder with major cardiometabolic and neurocognitive sequelae. It affects up to 1 billion people globally and is frequently attributable to excess weight [1]. Tirzepatide is a once-weekly, dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is FDA-approved for the treatment of moderate-to-severe OSA in adults with obesity.

Methods

The SURMOUNT-OSA program included two 52-week, randomized, double-blind, placebo-controlled, Phase 3 studies (Study 1 and Study 2). The objective of these analyses was to assess time to treatment effects for improvements in apnea-hypopnea index (AHI) and sleep apnea-specific hypoxic burden (SASHB), and how these changes correspond wi

SUBMITTER: Malhotra A 

PROVIDER: S-EPMC12723708 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature