Comparing Functional Consequences of Human iPSC-Microglia and Neural Stem Cell-Derived Extracellular Vesicles in Mitigating Cognitive Decline in Alzheimer's Disease.

ABSTRACT: Stem cell-derived extracellular vesicles (EVs) show promise as a therapeutic approach for neurodegenerative diseases, particularly Alzheimer's Disease (AD), where traditional regenerative interventions have achieved limited success. Our previous research demonstrated the neuroprotective benefits of human neural stem cell (hNSC)-derived EVs in 2- and 6-month-old AD mice (5xFAD) that exibited improved cognitive function and reduced AD-related neuropathology. This study aimed to compare the neuroprotective efficacy of EVs derived from two human cell lines: hNSCs from H9 embryonic stem cells and human iPSC-derived microglia (iMGLs). Additionally, we investigated the efficacy of an expanded EV treatment paradigm at subsequently longer time points. Three-month-old 5xFAD mice received weekly retr

SUBMITTER: Krattli RP 

PROVIDER: S-EPMC12723720 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature