Assessing the validity of leucine zipper constructs predicted by AlphaFold.

ABSTRACT: AP-1 transcription factors are a network of cellular regulators that combine in different dimer pairs to control a range of pathways involved in differentiation, growth, and cell death. They dimerize via leucine zipper coiled-coil domains that are preceded by a basic DNA binding domain. Depending on which AP-1 transcription factors dimerize, different DNA sequences will be recognized resulting in differential gene expression. The affinity of AP-1 transcription factors for each other dictates which dimers form. The relative concentration of AP-1 transcription factors varies with tissue type and environment, adding another layer of control to this integral network of cellular regulation. The development of artificial intelligence (AI)-based protein structure prediction methods gives us a new

SUBMITTER: Mitic I 

PROVIDER: S-EPMC12723748 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature