Preimplantation genetic testing for aneuploidy versus no genetic testing in couples undergoing intracytoplasmic sperm injection for severe male infertility: multicentre, open label, randomised controlled trial.

ABSTRACT:

Objective

To assess the efficacy of preimplantation genetic testing for aneuploidies (PGT-A) compared to intracytoplasmic sperm injection (ICSI) alone in couples undergoing ICSI treatment because of severe male infertility.

Design

Multicentre, open label, randomised controlled trial.

Setting

Four reproductive medicine centres across China.

Participants

450 couples with severe male factor infertility scheduled for ICSI were randomly assigned (1:1) to undergo PGT-A or not (225 couples in each group).

Interventions

ICSI with genetic testing of blastocysts before transfer in the PGT-A group, and ICSI without genetic testing for the no PGT-A group.

Main outcome measures

Primary outcomes were live birth after the first embryo transfer and cumulative liv

SUBMITTER: Lin X 

PROVIDER: S-EPMC12723751 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature