Divergent patterns of cognitive decline in preclinical Alzheimer's disease: implications for secondary prevention trials.

ABSTRACT:

Background

Alzheimer's disease biomarkers in cognitively unimpaired older adults are associated with later cognitive and clinical decline, yet substantial heterogeneity in the timing and rate of decline remains insufficiently characterized. This study aims to identify subgroups of cognitive decline among biomarker-defined cognitively unimpaired adults and determine baseline predictors of heterogeneity in preclinical Alzheimer's disease progression.

Methods

Longitudinal data was analyzed from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Study, which enrolled amyloid-positive participants, and the parallel LEARN Study, which enrolled amyloid-negative individuals meeting all other A4 criteria. Participants completed baseline amyloid PET, plasma P-tau217,

SUBMITTER: Li R 

PROVIDER: S-EPMC12723760 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature