Phenome-wide analysis of genetically imputed neuroimaging phenotypes reveals associations with psychiatric traits in a multi-ancestry cohort.

ABSTRACT:

Background

Understanding how variation in brain structure and function contributes to psychiatric and behavioral phenotypes remains a key challenge. The absence of neuroimaging data in many study samples limits this effort.

Methods

We used genome-wide association study (GWAS) summary statistics from the UK Biobank to impute 301 brain imaging-derived phenotype (IDP) genetic scores (IGS) in the Yale-Penn cohort, which is enriched for substance use disorders (n = 10,275; 52.8% European-like [EUR] and 47.2% African-like [AFR] genetic ancestry). The brain IDPs include white matter microstructure, regional volume, and resting-state functional connectivity measures, for which we generated IGS in the Yale-Penn participants. We then conducted a brain-wide phenome-wide association stu

SUBMITTER: Chihoub L 

PROVIDER: S-EPMC12723762 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature