Genetic Architecture of Alcohol Use Disorder in Nepal.

ABSTRACT: Alcohol use disorder (AUD) is a serious psychiatric condition associated with negative health and psychosocial consequences, comprising core symptoms of compulsive heavy drinking that impairs daily functioning. Genetic factors play a major role in AUD etiology, estimated to explain around 50% of variation in risk. Despite being a major global public health concern, the vast majority of genetic and epidemiological studies of AUD have been restricted to samples of European ancestry living in high-income countries. Using data from the Chitwan Valley Family Study, we perform the first comprehensive genetic study of AUD in a unique Nepalese sample of 10,032 individuals. We find significantly lower estimates of narrow-sense heritability (0.21, SE=0.06) compared to prior estimates from European a

SUBMITTER: Tubbs JD 

PROVIDER: S-EPMC12723783 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature