The impact of anxiety and depression on hematologic malignancy outcomes: a systematic review and meta-analysis.

ABSTRACT:

Background

Hematologic malignancies (HMs) are associated with high morbidity and mortality. Depression and anxiety, prevalent in patients with HM, may adversely impact survival, but their prognostic role remains unclear.

Materials and methods

This systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO (CRD42024568789). We searched PubMed, SCOPUS, and Web of Science for studies examining the association between depression or anxiety and survival outcomes in patients with HMs. Data extraction and quality assessment (using the Newcastle-Ottawa Scale and RoB2) were conducted independently by multiple reviewers. Random-effects meta-analyses were performed, with subgroup, sensitivity, and publication bias analyses. Additionally, meta-regressi

SUBMITTER: Salabat D 

PROVIDER: S-EPMC12723824 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature