Mitofusin 2 is required for preventing deoxynivalenol-induced porcine intestinal epithelial cell damage.

ABSTRACT:

Backgrounds

Deoxynivalenol (DON) is an abundant environmental pollutant in feed, posing serious health hazards to animals. However, whether DON triggers an imbalance in mitochondrial fission/fusion and the underlying mechanisms involved remain poorly understood. Our aim was to clarify whether mitochondrial fission or fusion proteins participated in DON-caused intestinal damage in pigs.

Methods

Firstly, two groups of weaning pigs were fed a basal diet, or basal diet supplemented with 4 mg DON/kg for 3 weeks. Additionally, another two groups of weaning pigs were given an oral gavage with 2 mg/kg body weight DON or an equivalent amount of normal saline. In addition, the involvement of mitochondrial fission or fusion proteins in DON-induced intestinal damage was further verified

SUBMITTER: Xiao K 

PROVIDER: S-EPMC12723839 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature