Combined bone marrow mesenchymal stem cell-derived nanovesicles and low-level laser therapy potentiate proliferation and osteogenesis of bone marrow mesenchymal stem cells.

ABSTRACT:

Background

Addressing the persistent challenge of bone defect repair requires innovative bioengineering strategies. Enhancing the biological activity of bone marrow mesenchymal stem cells (BMSCs) is pivotal for effective bone regeneration. This study develops a novel combinatorial bioengineering approach leveraging two distinct biotechnological modalities: low-level laser therapy (LLLT) and bone marrow mesenchymal stem cell-derived nanovesicles (BMSC-NVs). LLLT, a non-invasive biophysical stimulation technique with defined light parameters, is known to prime cellular responses. Concurrently, BMSC-NVs represent an emerging engineered cell-free therapeutic platform with significant promise for tissue regeneration. Thus, we hypothesize that combining LLLT's direct regulatory effects o

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12723869 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature