Fat-derived neural stem cells promote nerve regeneration following peripheral nerve injury.

ABSTRACT:

Background

Peripheral nerve injuries are associated with significant morbidity, particularly when primary surgical repair is delayed or impossible due to extensive nerve gaps. While advances in biomedical engineering have led to commercially available nerve guidance conduits tailored for such injuries, rates of sensory and motor recovery remain suboptimal following neurotmesis with gap defects beyond 3 cm. Cell therapy represents a promising treatment strategy to heal the injured peripheral nervous system, thought to promote tissue regeneration and enhance endogenous mechanisms of nerve repair to restore functionality. In this study, we explore the potential utility and efficacy of subcutaneous adipose tissue-derived neural stem cells in a nerve transection injury model.

Methods

SUBMITTER: Ott LC 

PROVIDER: S-EPMC12723924 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature